Teleopto Wireless Optogenetics

Wireless Optogenetics for Freely Moving Animals

Teleopto Wireless Optogenetics joins wireless LED light sources with implantable optic fibers. It includes a precise remote control to provide researchers with a turnkey stimulation system.

  • Receivers are very small and light weight
  • Has been used on mice and rats
  • Remote controller transmits stimulation signal to the receiver by infrared

Our lab has used the wireless Teleopto system daily for the last two years and we have been extremely pleased with our experience. We have been impressed by how readily available the staff at Amuza have been to assist with any questions we’ve had and their enthusiasm towards creating custom parts to meet the needs of our unique experiments. Based on our experiences with the Teleopto system, we highly recommend it to labs interested in initiating optogenetics experiments or transitioning from wired optogenetic systems.

Hirofumi Morishita

Associate Professor, Icahn School of Medicine at Mount Sinai

Starter kits contain the core components of Teleopto:

Teleopto Starter Kit, TeleSS:

1 each of Remote, Receiver (specify the type), Emitter, Charger, Stereotaxic Adapter,  Two Channel Trigger Cable and 3x LED fiber optics (specify).

Teleopto Starter Kit 2 channel pulse, TeleSS 2Ch:

1 each of 2 channel pulse Remote, 2 ch pulse Receiver (specify the size), Emitter, Charger, Holder, Two Channel Trigger Cable and 3x LED fiber optics (specify).

Lightweight Rechargeable Receivers

Teleopto’s lightweight receivers and bright LEDs provide up to 13 mW of light to the tip of an attached optic fiber. 1 g receivers are available for single color, single fiber applications. 2 g and 3 g receivers are available for dual color, dual LED optic fiber, and longer term/higher power stimulation.

2 channel pulse receivers
The new 2 channel pulse receivers are available in 1 g, 2 g, and 3 g sizes. As with our original pulse receivers, LEDs are ON while the remote is receiving a TTL pulse (or a trigger button is being pressed) and OFF in the absence of a pulse.

2 channel pulse receivers can be used in several different ways:

  • With 2 color LED fiber-optics for stimulation and inhibition at a single site
  • With bilateral implants, allowing independent control of each side.
  • With two single channel receivers (custom item, please inquire). This allows independent control of the two receivers, mounted at different sites or on different animals.

One limitation of the 2 channel pulse receivers is that only one channel can be activated at a time – both channels cannot be ON simultaneously.

Interchangeable LED Optic Fibers

Each unit comprises a three prong electrical connector, encapsulated LED, and implantable optical fiber. The LED can be blue, green, or yellow.

Single optic fiber: lightweight and robust enough to be inserted without a guide cannula.
LED probe without optic fiber: For brain surface stimulation.
Two colors LED optic fiber: Two independently controlled LEDs are attached to two 250 μm fibers bundled together.
Bilateral LED optic fiber: for bilateral stimulation.

Fiber length, fiber diameter, and the distance between the bilateral fibers can all be made to specification. Please ask about custom LED colors.

IR Remote Controller

The remote control allows direct control by push buttons for two separate channels. It also allows two channel control by TTL pulses from a programmable stimulator.

Synchronized light pulses are generated from the tip of the LED optic fiber (in pulse mode).

Accessories and Instruments

Accessories include: teleopto charger, infrared emitter (with or without clip), a stereotaxic adapter and a dummy receiver.

To further aid your research there are available instruments, such as a stimulator, a light power meter and a 6 channel hub.

User Publications

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories.
Izawa, S., Chowdhury, S., Miyazaki, T., Mukai, Y., Ono, D., Inoue, R., … & Terao, A. 
(2019) Science365(6459), 1308-1313.

“Novel Optogenetic Approach Reveals a Function of cGMP in Synaptic Plasticity and Memory”
Borovac, J.
(2019). Doctoral dissertation.

SatB2-Expressing Neurons in the Parabrachial Nucleus Encode Sweet Taste. 
Fu, O., Iwai, Y., Kondoh, K., Misaka, T., Minokoshi, Y., & Nakajima, K. I.
(2019). Cell reports27(6), 1650-1656.

Correlative study using structural MRI and super-resolution microscopy to detect structural alterations induced by long-term optogenetic stimulation of striatal medium spiny neurons. 
Abe, Y., Komaki, Y., Seki, F., Shibata, S., Okano, H., & Tanaka, K. F.
(2019). Neurochemistry international125, 163-174.

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain.
Sueda, R., Imayoshi, I., Harima, Y., & Kageyama, R.
(2019).  Genes & development.

Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory. 
Song, J., Shao, D., Guo, X., Zhao, Y., Cui, D., Ma, Q., … & Zheng, P.
(2019) Science advances5(2), eaat3210.

Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine‐depleted mice.
Jáidar, O., Carrillo‐Reid, L., Nakano, Y., Lopez‐Huerta, V. G., Hernandez‐Cruz, A., Bargas, J., … & Arbuthnott, G. W.
(2019) European Journal of Neuroscience.

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction.
Marek, R., Xu, L., Sullivan, R. K., & Sah, P.
(2018) Nature neuroscience21(5), 654.

Top-down cortical input during NREM sleep consolidates perceptual memory.
D. Miyamoto et al
(2016), Science

Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear.
Isosaka, T., Matsuo, T., Yamaguchi, T., Funabiki, K., Nakanishi, S., Kobayakawa, R., & Kobayakawa, K.
(2015). Cell163(5), 1153-1164.

A Top-Down Cortical Circuit for Accurate Sensory Perception.
Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., … & Murayama, M.
(2015). Neuron.

The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice.
Sato, M., Ito, M., Nagase, M., Sugimura, Y. K., Takahashi, Y., Watabe, A. M., & Kato, F.
(2015). Molecular brain,8(1), 22.

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