Microdialysis Probes

Advantages of Eicom Microdialysis Probes

Reliable. We have been manufacturing microdialysis probes for 20 years. We inspect all probes for functionality before shipping. Our team is in the U.S. to provide direct support. We have an integrated support/sales team so you can rely on our expertise. We are always just a call or email away.
Faster: We have a lot of inventory for immediate delivery at our San Diego Office and ship on the same day when we receive order before 1 pm (Pacific time). Please contact us to check our inventory.
Affordable. We offer our probes at a competitive price. This improves your bottom line without compromising the quality of the microdialysis products.
Flexible. Custom size probes are available even for low volume orders.

NEW TO EICOM PRODUCTS?

Call us for advice on which probes to use, or try a starter kit.

Our starter kits provide you with the microdialysis probes and accessories to see the quality of our products. Your research success is our top priority. Come see our probes, products, and expert support in action!

Note: the starter kits are available for new customers only.

About Microdialysis Probes

A microdialysis probe has a semi-permeable membrane. Our probes have a 220 µm outer diameter. The probe inlet connects to a syringe pump which continuously perfuses through the probe. As the perfusate travels through the probe, analytes cross the membrane and travel out the probe outlet into sample vials on a fraction collector or to a sample loop of an analytical system via a narrow tubing. This valuable tool enables sampling of rather low molecular weight compounds from within the extracellular space of tissues.

In the particular case of the brain and spinal cord, neurotransmitters are released to the extracellular space. This measurement has more meaning as informational transmitting than total tissue content. The collected extracellular fluid is used to determine the chemical composition with sub-nanomolar sensitivity and detect small changes due to manipulation, or related to a physiological/behavioral change. The microdialysis implanted animals behave close to normal conditions.

Brain Microdialysis, CX-I Series

  • Best for: Mice and short experiments.

  • Probes snap into guide cannulae.
  • Membrane material: artificial cellulose with a 50,000 Da MWCO*.
    Other MWCO membranes available by special order.
  • Membrane ID/OD: 200/220 µm.
  • Use of a harness system to prevent pulling out
    the probe is recommended.

*MWCO = Molecular Weight Cut Off

 

Guide Cannula CXG-X

  • Shaft: 0.5 mm OD stainless steel.
  • Length is designated by X.
  • Cup thickness is 2.5 mm.

X is the length of the guide cannula. Available in X = 2, 4, 6, 8, 10, 12 mm.

Y is the length of the membrane. Available in Y = 0.5 to 10 mm, in increments of 0.5 mm.

For faster delivery, consider ordering X = 4, 8, 12 mm and Y = 1, 2, 3 mm.

Other custom lengths may be available. Please contact a sales representative for details.

 

CX-I Series
CX-I-X-0YProbe; 1 each
CXG-XGuide cannulae; 3 pcs/pk
CXD-XDummy probes; 3 pcs/pk
CXSG-XStereotaxic adaptor of guide; 1 each
SterileSterilized with ethylene monoxide gas before shipping

Microinjection Cannulae

CXMI Series
CXMI-XMicroinjection cannulae; 3 pcs/pk
OD shaft: 0.35 mm | OD inlet: 0.5 mm
CXG-XGuide Cannulae; 3 pcs/pk
CXD-XDummy Probes; 3 pcs/pk
CXSG-XStereotaxic Adaptor of Guide; 1 each
CXMI(T)-X

Small microinjection cannulae; 3 pcs/pk
OD shaft: 0.15 mm | OD inlet: 0.3 mm

CXG(T)-XSmall guide cannulae; 3 pcs/pk
OD 0.3 mm
CXD(T)-XSmall dummy probe; 3 pcs/pk
CXSG(T)-XStereotaxic adapter for implanting small guide, CXG(T)-X; 1 each

Brain Microdialysis, AZ Series

    • Best for: Rats or long term experiments.

    • Secure attachment to the guide cannula with a threaded cap nut.

    • Membrane material: Artificial cellulose with 50,000 Da MWCO.

    • Membrane ID/OD: 200/220 µm.

    • Available in custom lengths at no additional charge.

Inlet Tubing
Inner 0.04 mm ID PFS*
Outer 0.63 mm OD SUS**

Outlet Tubing
Inner 0.075 mm ID PFS
Outer 0.63 mm OD SUS

Shaft
0.30 mm OD SUS

Membrane
0.22 mm OD, 0.20 mm ID
Artificial Cellulose

*PFS Polyimide Fused Silica
**SUS Passivated Stainless Steel 316

Guide Cannula AG-X

  • 0.5 mm OD stainless steel.
  • Fuses to skull with acrylic resin/dental cement.

Cap Nut AC-5

  • 5 mm OD.
  • Does not fuse with acrylic resin/dental cement.

X is the length of the guide cannula. Available in X = 2, 4, 6, 8, 10, 12 mm.

Y is the length of the membrane. Available in Y = 0.5 to 10 mm, in increments of 0.5 mm.

For faster delivery, consider ordering X = 4, 8, 12 mm and Y = 1, 2, 3 mm.

AZ Series
AZ-X-0YProbe; 1 each
AG-XGuide cannulae; 3 pcs/pk
AD-XDummy probes; 3 pcs/pk
SAG-XStereotaxic adaptor of guide; 1 each
AC-5Cap nut; 3 pcs/pk
SterileSterilized with ethylene monoxide gas before shipping
AMI-XInjection cannulae; 3 pcs/pk (AZ without membrane)

Microinjection + Microdialysis, MI-AZ

  • Injection cannula (0.075/0.15 mm ID/OD) outside the membrane.

  • Position of injection cannula tip specified by customer. Standard is at the middle of membrane because it works better to monitor the effect of injection than if positioned at membrane tip.

  • Guide cannula OD is 0.7 mm.

  • Refer to AZ probe for X and Y specifications.

  • For injection cannula without microdialysis, please see bottom of each table in previous sections.

Please specify probe dimensions upon ordering. All probes are tailor made.
Please allow up to 3 weeks for delivery.
X for shaft length and Y for membrane length. X = 1 to 20 mm, Y = 0.5 to 4 mm

MI-AZ Series
MI-AZ-X-0YProbe with microinjection cannula; 1 each
MI-AG-XGuide cannulae for MI-AZ; 3 pcs/pk
MI-AD-XDummy probes for MI-AG; 3 pcs/pk
MI-SAG-XStereotaxic adaptor of guide, MI-AG; 1 each
AC-5Cap nut; 3 pcs/pk
SterileSterilized with ethylene monoxide gas before shipping

Non-Metal Microdialysis Probes and Guides, C-I

  • Best For: MRI and PET studies.

  • FEP tubing used for inlet and outlet.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Guide cannula OD: 0.66 mm.

Please order by specifying probe dimensions. All custom made. Allow us 3 weeks for delivery.
X for shaft length and Y for membrane length. X = 1 to 20 mm; Y = 0.5 to 4 mm

C-I Series
C-I-X-0YProbe; 1 each
CG-X (FS)Guide cannulae; 3 pcs/pk
CD-X (FS)Dummy probes; 3 pcs/pk
AC-5Cap nut; 3 pcs/pk

Extra Small Brain Probe, DZ

  • Best For: Direct implantation without guide cannula.
  • Smallest and least expensive probe.

  • Great for mice.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Use probe holder ATH-02 to implant.

  • Order by specifying probe dimensions. X for shaft length and Y for membrane length.

  • X = 0.5 to 10 mm, Y = 0.5 to 4 mm.

DZ Probe
DZ-X-0YProbe; 1 each
ATH-02Probe holder for DZ type

Linear Probe, OP

  • Best For: Skin and other organs.

  • Needle on one end for easy implantation.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • 40 µm diameter platinum wire inside supports membrane.

  • Flexible tubing is polyethylene (PE-10).

  • Flexible tubing OD: 0.61 mm.

  • Inlet and outlet OD: 0.33 mm (= 26 G needle).

Order by specifying probe dimensions. X for each side of PE-10 tubing length and Y for membrane length.
X = 50 to 200 mm,  Y = 1 to 20 mm, OP-100-10 is the most popular size.

OP Probe
OP-X-0YProbe; 1 each

Flexible Concentric Probe, TP

  • Best For: Blood vessels, GI tract.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Flexible shaft is TFE (Teflon®).

  • Flexible shaft OD: 0.6 mm.

  • Inlet and outlet OD: 0.33 mm (= 26 G needle).

  • 0.04 mm fused silica tubing inside to minimize dead volume.

Order by specifying probe dimensions. X for TFE tubing length and Y for membrane length.
X = 10 to 200 mm, Y = 1 to 20 mm, TP-100-10 is the most popular size.

TP Probe
TP-X-0YFlexible concentric probe; 1 each

Let’s Get Started!