Last Updated on January 6, 2020

When it comes to neurotransmitter detection such as Dopamine, Serotonin, Norepinephrine, Glutamate, GABA, Acetylcholine, etc., in microdialysis samples, tissue homogenates, blood plasma, and others, there are three (3) main methods; LC-Mass Spectrometry (LC-MS), HPLC-ECD (Electrochemical Detection) & ELISA/Radioimmunoassays.

The first option is LCMS, it provides the highest sensitivity and specificity to the detecting neurotransmitters and also the most expensive option. The price range is between US$200,000 to $600,000.

The second method is HPLC-ECD which is much more cost affordable while offering great sensitivity. The price range is between US$20,000 to $60,000.

The third method is ELISA or Radioimmunoassays which offers less sensitivity. There is also a concern of selectivity due to cross-talk among antibodies.

Therefore, when choosing which method would work best for you, we would recommend HPLC-ECD.