We have received an NIH Grant

We have received an NIH Grant

We are excited to announce that Amuza Inc have been awarded an R41 Technology Transfer grant by the National Institute of Neurological Disorders (NINDS/NIH, USA) to develop “a unified system of wireless optogenetics and brain microdialysis”. The grant proposal was based on research which combined Amuza’s HPLC-ECD, microdialysis, and optogenetics instruments.

The funding is for Phase I (prototype development and validation) of a Small Business Technology Transfer (STTR) project in collaboration with Drs. Nobuyoshi Suto (The Scripps Research Institute), Thomas Jhou (Medical University of South Carolina) and Matthew Buczynski (Virginia Tech).

After research and commercialization phases have  been completed the final opto-dialysis system will be available from Amuza as well. We are currently undertaking the pilot experiments in freely moving animals (both rats and mice) using our opto-dialysis prototypes. We will post the results as they become available. Please stay tuned!

New Microdialysis Fraction Collector, FC-90

New Microdialysis Fraction Collector, FC-90

We are pleased to announce the launch of a new Microdialysis Fraction Collector, Model FC-90, designed by Amuza.

The new FC-90 Microdialysis Fraction Collector saves lab space and your time when collecting microdialysis samples from multiple animals, up to 4 at once. The FC-90’s quiet operation and narrow footprint are ideal for small spaces. Programmed and controlled by Android™ devices via Bluetooth. Robustly designed for microdialysis.

 

The Android robot is reproduced or modified from work created and shared by Google and used according to terms described in the Creative Commons 3.0 Attribution License.

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Fast Microdialysis for Serotonin and Dopamine

Fast Microdialysis for Serotonin and Dopamine

Eicom can increase the throughput, sensitivity, and temporal resolution of your next microdialysis experiment. Fast microdialysis allows basal level monitoring of dopamine and serotonin in mice with 3 minute online HPLC analyses and 6 minute sampling times. These conditions allow a detection limit for serotonin of 0.8 fMol with an Eicom HTEC-500 HPLC.

Developed by neuroscientists Anne Andrews and Hongyan Yang at UCLA in conjunction with Eicom, this application makes full use of the short analysis time by staggering injections from two different animals onto one Eicom HTEC 500 HPLC-ECD equipped with a PP-ODS II separation column.

The 6 minute sample time has already proven useful in unmasking physiologically relevant changes in extracellular serotonin levels too fast to examine with standard 20-minute samples. Furthermore, online microdialysis allowed them to troubleshoot microdialysis sampling at the beginning of their experiments instead of after hours of collection.

Two Eicom EAS-20s autoinjectors are programmed to collect 6-minute samples from two animals and alternate making injections on the HPLC. This allows 2 complete runs, one from each animal, in each 6-minute chromatogram.

Questions?